Journal article
CenTauR: Toward a universal scale and masks for standardizing tau imaging studies
VL Villemagne, A Leuzy, SS Bohorquez, S Bullich, H Shimada, CC Rowe, P Bourgeat, B Lopresti, K Huang, N Krishnadas, J Fripp, Y Takado, A Gogola, D Minhas, R Weimer, M Higuchi, A Stephens, O Hansson, V Doré
Alzheimer S and Dementia Diagnosis Assessment and Disease Monitoring | Published : 2023
DOI: 10.1002/dad2.12454
Abstract
INTRODUCTION: Recently, an increasing number of tau tracers have become available. There is a need to standardize quantitative tau measures across tracers, supporting a universal scale. We developed several cortical tau masks and applied them to generate a tau imaging universal scale. METHOD: One thousand forty-five participants underwent tau scans with either 18F-flortaucipir, 18F-MK6240, 18F-PI2620, 18F-PM-PBB3, 18F-GTP1, or 18F-RO948. The universal mask was generated from cognitively unimpaired amyloid beta (Aβ)− subjects and Alzheimer's disease (AD) patients with Aβ+. Four additional regional cortical masks were defined within the constraints of the universal mask. A universal scale, the..
View full abstractGrants
Awarded by National Health and Medical Research Council
Funding Acknowledgements
The research was supported by the Australian federal government through NHMRC grants APP1132604, APP1140853, and APP1152623 and by a grant from Enigma Australia.